- Summary
Sulfur hexafluoride is a medication used in ultrasound to enhance viewing of blood vessels and the urinary tract.
- Brand Names
Lumason, Sonovue
- Generic Name
- Sulfur hexafluoride
- DrugBank Accession Number
- DB11104
- Background
Sulfur hexafluoride is an ultrasound contrast agent indicated for use•in echocardiography to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border in adult patients with suboptimal echocardiograms•in ultrasonography of the liver for characterization of focal liver lesions in adult and pediatric patients
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 146.05
Monoisotopic: 145.962490152 - Chemical Formula
- F6S
- Synonyms
- hexafluoridosulfur
- Sulfur fluoride
- Sulfur hexafluoride
- sulfur(6+) fluoride
- sulfur(VI) fluoride
- Sulphur hexafluoride
Pharmacology
- Indication
Echocardiography: Sulfur hexafluoride is indicated for use in adult patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricularendocardial border.Ultrasonography of the Liver: Sulfur hexafluoride is indicated for use with ultrasound of the liver in adult and pediatric patients to characterize focal liver lesions.
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- Contraindications & Blackbox Warnings
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- Pharmacodynamics
Sulfur hexafluoride provides useful echocardiographic signal intensity for two minutes after the injection. Sulfur hexafluoride microspheres are destroyed and contrast enhancement decreases as the mechanical index increases (values of 0.8 or less are recommended).For ultrasonography of the liver, Sulfur hexafluoride provides dynamic patterns of differential signal intensity enhancement between focal liver lesions and liver parenchyma during the arterial, portal venous, and late phase of signal intensity enhancement of the microvasculature.
- Mechanism of action
Within the blood, the acoustic impedance of Lumason microspheres is lower than that of the surrounding non-aqueous tissue. Therefore, an ultrasound beam is reflected from the interface between the microspheres and the surrounding tissue. The reflected ultrasound signal provides a visual image that shows a contrast between the blood and the surrounding tissues.
- Absorption
The pharmaco*kinetic of the SF6 gas component of Lumason was evaluated in 12 healthy adult subjects (7 men and 5 women). After intravenous bolus injections of 0.03 mL/kg and 0.3 mL/kg of Lumason, corresponding to approximately 1 and 10 times the recommended doses, concentrations of SF6 in blood peaked within 1 to 2 minutes for both doses.
- Volume of distribution
In a study of healthy subjects, the mean values for the apparent steady-state volume of distribution of SF6 were 341 L and 710 L for Lumason doses of 0.03 mL/kg and 0.3 mL/kg, respectively. Preferential distribution to the lung is likely responsible for these values.
- Protein binding
Not Available
- Metabolism
SF6 undergoes little or no biotransformation; 88% of an administered dose is recovered unchanged in expired air.
- Route of elimination
The SF6 component of Lumason is eliminated via the lungs.
- Half-life
The terminal half-life of SF6 in blood was approximately 10 minutes for the 0.3 mL/kg dose. (At the 0.03 mL/kg dose, terminal half-life could not be estimated.)
- Clearance
Not Available
- Adverse Effects
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- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available- Food Interactions
- No interactions found.
Products
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- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Sonovue Injection, powder, for solution 8 μl/ml Intravenous Bracco International B.V. 2016-09-08 Not applicable Sonovue Powder, for suspension 8 mcL / mL Intravenous; Intravesical Bracco Imaging S.P.A. 2016-09-22 Not applicable - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image LumaSon Sulfur hexafluoride (60.7 mg/1mg) + 1,2-Distearoyllecithin (.19 mg/1mg) + Sodium 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (.19 mg/1mg) Injection, powder, lyophilized, for suspension; Kit Intravenous; Intravesical Bracco Diagnostics Inc 2020-01-15 Not applicable LumaSon Sulfur hexafluoride (60.7 mg/1mg) + 1,2-Distearoyllecithin (.19 mg/1mg) + Sodium 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (.19 mg/1mg) Kit Intravenous; Intravesical Bracco Suisse SA 2015-01-15 Not applicable Lumason Sulfur hexafluoride (60.7 mg/1mg) + 1,2-Distearoyllecithin (.19 mg/1mg) + Sodium 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (.19 mg/1mg) Injection, powder, lyophilized, for suspension Intravenous; Intravesical Bracco Diagnostics Inc 2021-04-01 Not applicable
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as other non-metal halides. These are inorganic compounds containing 'other non-metals' and halogen.
- Kingdom
- Inorganic compounds
- Super Class
- hom*ogeneous non-metal compounds
- Class
- Other non-metal halides
- Sub Class
- Not Available
- Direct Parent
- Other non-metal halides
- Alternative Parents
- Not Available
- Substituents
- Other non-metal halide
- Molecular Framework
- Not Available
- External Descriptors
- sulfur coordination entity (CHEBI:30496)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- WS7LR3I1D6
- CAS number
- 2551-62-4
- InChI Key
- SFZCNBIFKDRMGX-UHFFFAOYSA-N
- InChI
InChI=1S/F6S/c1-7(2,3,4,5)6
- IUPAC Name
hexafluoro-λ⁶-sulfane
- SMILES
FS(F)(F)(F)(F)F
References
- General References
- FDA label [Link]
- External Links
- KEGG Drug
- D05962
- PubChem Compound
- 17358
- PubChem Substance
- 347827897
- ChemSpider
- 16425
- RxNav
- 1599276
- ChEBI
- 30496
- ChEMBL
- CHEMBL1796998
- ZINC
- ZINC000245224194
- Wikipedia
- Sulfur_hexafluoride
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Active Not Recruiting Diagnostic Abdominal Injuries / Falls, Accidental / Motor Vehicle Injury / Physical Abuse 1 4 Completed Diagnostic Abdominal Trauma 1 4 Completed Diagnostic Hepatic Disease 1 4 Completed Other Hepatocellular Carcinoma 1 4 Recruiting Diagnostic Renal Malignant Tumor 1
Pharmacoeconomics
- Manufacturers
Not Available
- Packagers
Not Available
- Dosage Forms
Form Route Strength Injection, powder, lyophilized, for suspension Intravenous; Intravesical Injection, powder, lyophilized, for suspension; kit Intravenous; Intravesical Kit Intravenous; Intravesical Injection, powder, for solution Intravenous 8 μl/ml Powder Intravenous; Parenteral 8 MCG/ML Powder, for suspension Intravenous; Intravesical 8 mcL / mL Injection, powder, for solution Intravenous 8 microlitres/ml - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US5686060 No 1997-11-11 2017-11-11 US10232061 No 2019-03-19 2038-07-06 US10335502 No 2019-07-02 2038-07-06 US11723869 No 2019-05-15 2039-05-15
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 2.28 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 18.44 m3·mol-1 Chemaxon Polarizability 7.11 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 120.86147 predicted
DeepCCS 1.0 (2019) [M+H]+ 122.782585 predicted
DeepCCS 1.0 (2019) [M+Na]+ 131.15828 predicted
DeepCCS 1.0 (2019)
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Learn moreDrug created at December 03, 2015 16:51 / Updated at June 03, 2022 07:24
