Ankur Choudhary
Pharmaceutical GMP, GLP & Validation Expert | Founder of Pharmaguideline | QA/QC, Auditing & Regulatory Compliance Specialist | Blogger | Youtuber
Published Mar 22, 2023
There are several reasons why 70% isopropyl alcohol is used as a disinfectant. First, it has been found to be more effective at killing microorganisms than higher concentrations of isopropyl alcohol. This is because the water content in the 70% IPA solution allows for better penetration into the microorganisms and denaturation of proteins.
On the other hand, solutions with lower alcohol concentration (less than 50%) are not as effective against microorganisms, while those with higher concentration (above 90%) evaporate too quickly, leaving insufficient contact time to penetrate the cell wall of the microorganism.
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Another reason why 70% isopropyl alcohol is preferred as an alcohol disinfectant is that it is less volatile than higher concentrations, making it easier to handle and safer to use. Additionally, 70% isopropyl alcohol is less likely to cause skin irritation or damage to surfaces, compared to higher concentrations.
Overall, the 70% concentration of isopropyl alcohol strikes a balance between its antimicrobial effectiveness, ease of use, and safety, making it an ideal choice for disinfecting a wide range of surfaces and equipment in healthcare, laboratory, and household settings.
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